Endocrine Abstracts

Introduction: Children with long-standing primary hypothyroidism usually have growth retardation, neurodevelopmental impairment, and delayed puberty. However, paradoxical precocious puberty, namely Van Wyk-Grumbach syndrome (VWGS), has been described. The postulated mechanism is high levels of TSH stimulate gonadal FSH receptors, resulting in ovarian over-stimulation and precocious puberty. Since the enlarged ovarian cyst is commonly found in VWGS, malignancy is often suspecte...